Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784560 | 1.00 | RET (0.50) | RETNR1H4KDM4EPOLBTP53 | |
| SCHEMBL5784552 | 1.00 | RET (0.50) | RETNR1H4KDM4EPOLBTP53 | |
| SCHEMBL7476044 | 0.92 | RET (0.48) | RETNR1H4KDM4EPOLBMAPT | |
| SCHEMBL5784962 | 0.92 | RET (0.48) | RETNR1H4KDM4EPOLBMAPT | |
| SCHEMBL5784953 | 0.92 | RET (0.48) | RETNR1H4KDM4EPOLBMAPT | |
| SCHEMBL5783058 | 0.91 | RET (0.47) | RETNR1H4KDM4EMEN1KMT2A | |
| SCHEMBL5783053 | 0.91 | RET (0.47) | RETNR1H4KDM4EMEN1KMT2A | |
| SCHEMBL5783077 | 0.90 | RET (0.48) | RETPOLBMAPTMEN1KMT2A | |
| SCHEMBL7474780 | 0.90 | RET (0.48) | RETPOLBMAPTMEN1KMT2A | |
| SCHEMBL5783080 | 0.90 | RET (0.48) | RETPOLBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |