SCHEMBL7477600

SCHEMBL7477600

Cc1c[c]cc(C)c1SC(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16707482 0.73 SMN1; SMN2 (0.38) SMN1; SMN2
SCHEMBL16707513 0.73 HTR2A (0.39) HTR2ASMN1; SMN2
SCHEMBL900413 0.73
SCHEMBL16707484 0.71 SMN1; SMN2 (0.41) HTR2ASMN1; SMN2
SCHEMBL7473611 0.70 SMN1; SMN2 (0.30) SMN1; SMN2
SCHEMBL16707488 0.68 HTR2A (0.35) HTR2ASMN1; SMN2
SCHEMBL16707486 0.68 HTR2A (0.32) HTR2A
SCHEMBL455674 0.67
SCHEMBL16707480 0.67 KDM4E (0.33) HTR2ASMN1; SMN2
SCHEMBL13725004 0.66 KDM4E (0.36) HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194417-A1 PHENOXY FLUOROPYRIMIDINES BAYER AG (DE) 2002-04-10 EP claimed
WO-2000078733-A1 PHENOXY FLUOROPYRIMIDINES BAYER AKTIENGESELLSCHAFT (DE) 2000-12-28 WO claimed
EP-1194417-A1 PHENOXY FLUOROPYRIMIDINES BAYER AG (DE) 2002-04-10 EP disclosed
WO-2000078733-A1 PHENOXY FLUOROPYRIMIDINES BAYER AKTIENGESELLSCHAFT (DE) 2000-12-28 WO disclosed