Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 18/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6920754 | 0.94 | PLAU (0.77) | PLAUPTGS2 | |
| Bromide SCHEMBL7388801 | 0.93 | PLAU (0.79) | PLAU | |
| SCHEMBL6927014 | 0.88 | PLAU (1.00) | PLAU | |
| Hydrochloric Acid SCHEMBL6928156 | 0.87 | PLAU (0.98) | PLAU | |
| Bromide SCHEMBL6923436 | 0.87 | PLAU (0.77) | PLAU | |
| SCHEMBL7391881 | 0.86 | PLAU (0.93) | PLAU | |
| Bromide SCHEMBL7414776 | 0.85 | PLAU (0.77) | PLAU | |
| Bromide SCHEMBL7387956 | 0.83 | PLAU (0.64) | PLAUCSNK2A1 | |
| Bromide SCHEMBL6921441 | 0.83 | PLAU (0.77) | PLAUPTGS2CSNK2A1 | |
| Bromide SCHEMBL7822641 | 0.83 | PLAU (0.77) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054886-B1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-09-04 | — | — | EP | disclosed |