Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 1.00 |
| ▸ | HTR1B | P28222 | 19/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693791 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8404067 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8404064 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4339517 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8645008 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8474241 | 0.83 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8471754 | 0.83 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL4578434 | 0.78 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7481503 | 0.78 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4579728 | 0.78 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5998440-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARPE & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | disclosed |