SCHEMBL7478348

SCHEMBL7478348

COc1ccc2ccc(S(=O)(=O)N(CC(=O)OC(C)(C)C)[C@H]3CCN(Cc4cc(C#N)ccc4N)C3=O)cc2c1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.57
F2 P00734 12/20 0.57
KLK6 Q92876 3/20 0.47
PLG P00747 1/20 0.45
PLAT P00750 1/20 0.45
PROC P04070 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7481448 0.92 F10 (0.65) F10F2KLK6PLGPLAT
SCHEMBL7486234 0.91 F10 (0.66) F10F2KLK6PLGPLAT
SCHEMBL2329284 0.86 F10 (0.52) F10F2KLK6PLGPLAT
SCHEMBL2328153 0.85 F10 (0.75) F10F2KLK6PLGPLAT
SCHEMBL2325338 0.84 KLK6 (0.56) F10F2KLK6PLGPLAT
SCHEMBL2333705 0.83 F10 (0.57) F10F2KLK6PLGPLAT
SCHEMBL2332785 0.81 F10 (0.65) F10F2KLK6PLGPLAT
SCHEMBL2329560 0.78 F10 (0.67) F10F2KLK6PLGPLAT
SCHEMBL8425526 0.77 F10 (0.61) F10F2KLK6PLGPLAT
SCHEMBL2327028 0.77 F10 (0.64) F10F2KLK6PLGPLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0894088-A4 SUBSTITUTED SULFONIC ACID N- (AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLAMIDE COMPOUNDS RHONE POULENC RORER PHARMA (US) 2001-12-05 EP disclosed
US-6034093-A Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 2000-03-07 US disclosed
EP-0894088-A1 SUBSTITUTED SULFONIC ACID N- (AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-02-03 EP disclosed
WO-1998024784-A1 SUBSTITUTED SULFONIC ACID N-[(AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-06-11 WO disclosed