Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 16/20 | 0.82 |
| ▸ | KIT | P10721 | 3/20 | 0.82 |
| ▸ | KDR | P35968 | 12/20 | 0.81 |
| ▸ | MET | P08581 | 3/20 | 0.78 |
| ▸ | AXL | P30530 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223563 | 0.92 | PDGFRA (0.81) | PDGFRAKITKDRMETAXL | |
| SCHEMBL1878386 | 0.92 | PDGFRA (0.92) | PDGFRAKITKDRAXL | |
| SCHEMBL5824959 | 0.90 | PDGFRA (1.00) | PDGFRAKITKDRMETAXL | |
| SCHEMBL7490931 | 0.90 | PDGFRA (1.00) | PDGFRAKITKDR | |
| SCHEMBL7490630 | 0.89 | PDGFRA (0.86) | PDGFRAKITKDR | |
| SCHEMBL8070553 | 0.89 | PDGFRA (0.94) | PDGFRAKITKDR | |
| SCHEMBL7477642 | 0.88 | AXL (0.87) | PDGFRAKITKDRAXL | |
| SCHEMBL29973354 | 0.87 | PDGFRA (0.95) | PDGFRAKDR | |
| SCHEMBL27081475 | 0.87 | PDGFRA (0.95) | PDGFRAKDR | |
| SCHEMBL1877226 | 0.86 | PDGFRA (0.84) | PDGFRAKITKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |