Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 1.00 |
| ▸ | HTR1B | P28222 | 20/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.78 |
| ▸ | HTR1F | P30939 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473182 | 0.92 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7479858 | 0.91 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7478714 | 0.89 | HTR1D (0.79) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7477108 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL7481703 | 0.87 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8115828 | 0.85 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| Oxalic Acid SCHEMBL8111341 | 0.85 | HTR1D (0.73) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8111059 | 0.84 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8110242 | 0.83 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8111210 | 0.82 | HTR1D (1.00) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6048878-A | Substituted piperidine derivatives as selective agonists of 5-HT receptors | MERCK SHARP & DOHME LTD. (GB) | 2000-04-11 | — | — | US | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |