Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 5/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750560 | 0.94 | HTT (0.56) | ARKCNH2BRD4HTTTDP1 | |
| Ammonia Solution, Strong SCHEMBL747955 | 0.85 | AR (0.51) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL748865 | 0.81 | HTT (0.62) | ARKCNH2BRD4HTTTDP1 | |
| Formic Acid SCHEMBL747954 | 0.81 | HTT (0.49) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2264757 | 0.79 | HTT (0.57) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2262571 | 0.77 | AR (0.60) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2266350 | 0.77 | HTT (0.62) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL12368262 | 0.77 | MAPT (0.70) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2265318 | 0.76 | MAPT (0.54) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2264697 | 0.75 | HTT (0.57) | ARKCNH2BRD4HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430024-A1 | [1,2,4]TRIAZOLO [4,3-B]PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | AstraZeneca AB (SE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |