Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479675 | 0.95 | ACE2 (0.45) | ACE2ACEALDH1A1MAPK1OPRK1 | |
| SCHEMBL22654352 | 0.85 | ACE2 (0.32) | ACE2ACEMAPT | |
| SCHEMBL5869636 | 0.82 | ACE2 (0.48) | ACE2ACEALDH1A1MAPK1KDM4E | |
| SCHEMBL5869646 | 0.82 | ACE2 (0.48) | ACE2ACEALDH1A1MAPK1KDM4E | |
| SCHEMBL5869641 | 0.82 | ACE2 (0.48) | ACE2ACEALDH1A1MAPK1KDM4E | |
| SCHEMBL22654353 | 0.81 | ACE2 (0.33) | ACE2ACEMAPT | |
| SCHEMBL5869918 | 0.76 | CASR (0.47) | ACE2ACEMAPTNTSR1 | |
| SCHEMBL5869775 | 0.76 | ACE (0.47) | ACE2ACENTSR1 | |
| SCHEMBL5869803 | 0.76 | ACE (0.47) | ACE2ACENTSR1 | |
| SCHEMBL5869807 | 0.76 | ACE (0.47) | ACE2ACENTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |