Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889405 | 0.93 | SLC6A4 (0.72) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL3884378 | 0.93 | SLC6A4 (0.72) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL3896858 | 0.93 | SLC6A4 (0.72) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL3889413 | 0.93 | SLC6A4 (0.72) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL3898028 | 0.93 | SLC6A4 (0.72) | SLC6A4HTR1ADRD1SLC6A2HTR1B | |
| SCHEMBL5785429 | 0.78 | SLC6A4 (0.71) | SLC6A4HTR1BHTR2A | |
| SCHEMBL5784929 | 0.78 | SLC6A4 (0.71) | SLC6A4HTR1BHTR2A | |
| SCHEMBL5785421 | 0.78 | SLC6A4 (0.71) | SLC6A4HTR1BHTR2A | |
| SCHEMBL5784935 | 0.78 | SLC6A4 (0.71) | SLC6A4HTR1BHTR2A | |
| SCHEMBL5784926 | 0.78 | SLC6A4 (0.71) | SLC6A4HTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1160332-C | N-aryloxyethylamine derivatives for treatment of depression | — | 2004-08-04 | — | — | CN | disclosed |
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| CN-1303373-A | N-Aryloxyethylamine derivatives for treatment of depression | AMERICAN HOME PROD (US) | 2001-07-11 | — | — | CN | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |