Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 1.00 |
| ▸ | BRAF | P15056 | 10/20 | 0.90 |
| ▸ | RAF1 | P04049 | 4/20 | 0.90 |
| ▸ | CSF1R | P07333 | 2/20 | 0.84 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.82 |
| ▸ | FLT4 | P35916 | 3/20 | 0.82 |
| ▸ | MET | P08581 | 1/20 | 0.82 |
| ▸ | KIT | P10721 | 1/20 | 0.82 |
| ▸ | SRC | P12931 | 1/20 | 0.82 |
| ▸ | FLT1 | P17948 | 1/20 | 0.82 |
| ▸ | FLT3 | P36888 | 2/20 | 0.79 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.78 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013038 | 0.95 | BRAF (1.00) | KDRBRAFRAF1CSF1RPDGFRB | |
| SCHEMBL1013484 | 0.92 | BRAF (1.00) | KDRBRAFRAF1CSF1RPDGFRB | |
| SCHEMBL7480612 | 0.92 | KDR (1.00) | KDRBRAFRAF1CSF1RPDGFRA | |
| SCHEMBL1013810 | 0.90 | BRAF (1.00) | KDRBRAFRAF1CSF1RPDGFRB | |
| SCHEMBL1015856 | 0.89 | BRAF (1.00) | KDRBRAFRAF1CSF1RPDGFRB | |
| SCHEMBL5202980 | 0.89 | KDR (0.85) | KDRBRAFRAF1CSF1RPDGFRA | |
| SCHEMBL1015284 | 0.88 | BRAF (1.00) | KDRBRAFRAF1MAPK14TNNI3K | |
| SCHEMBL5206337 | 0.88 | KDR (0.84) | KDRBRAFRAF1CSF1RPDGFRA | |
| SCHEMBL1012696 | 0.88 | BRAF (1.00) | KDRBRAFRAF1MAPK14TNNI3K | |
| SCHEMBL1780469 | 0.87 | BRAF (0.84) | KDRBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | claimed |
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |