SCHEMBL7480392

SCHEMBL7480392

COc1cc2nccc(Oc3ccc(NC(=O)c4ccc(Br)cc4)cc3)c2cc1OC

nearest known ligand 0.72

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AXL P30530 3/20 0.72
PDGFRA P16234 15/20 0.70
KDR P35968 14/20 0.70
KIT P10721 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7479728 0.91 AXL (0.73) AXLPDGFRAKDRKIT
SCHEMBL7486104 0.91 AXL (0.73) AXLPDGFRAKDRKIT
SCHEMBL7482291 0.91 AXL (0.73) AXLPDGFRAKDRKIT
SCHEMBL7482754 0.91 AXL (0.73) AXLPDGFRAKDRKIT
SCHEMBL7488408 0.90 KDR (0.85) PDGFRAKDR
SCHEMBL5824922 0.90 PDGFRA (0.83) AXLPDGFRAKDRKIT
SCHEMBL7486904 0.90 AXL (0.72) AXLPDGFRAKDRKIT
SCHEMBL4223563 0.89 PDGFRA (0.81) AXLPDGFRAKDRKIT
SCHEMBL7484817 0.89 AXL (0.74) AXLPDGFRAKDRKIT
SCHEMBL7485755 0.89 AXL (0.74) AXLPDGFRAKDRKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0860433-B1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BREWERY (JP) 2002-07-03 EP claimed
US-6143764-A ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS KIRIN BEER KABUSHIKI KAISHA (JP) 2000-11-07 US claimed
EP-0860433-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 1998-08-26 EP claimed
EP-0860433-B1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BREWERY (JP) 2002-07-03 EP disclosed
US-6143764-A ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS KIRIN BEER KABUSHIKI KAISHA (JP) 2000-11-07 US disclosed
EP-0860433-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 1998-08-26 EP disclosed