SCHEMBL7480398

SCHEMBL7480398

COc1ccccc1Oc1c(NS(=O)(=O)c2cccs2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 18/20 0.72
EDNRA P25101 18/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7479954 0.86 EDNRB (0.72) EDNRBEDNRA
SCHEMBL14380727 0.84 EDNRB (1.00) EDNRBEDNRA
SCHEMBL1383888 0.83 EDNRB (0.74) EDNRBEDNRA
SCHEMBL7483156 0.83 EDNRB (0.78) EDNRBEDNRA
SCHEMBL7200340 0.82 EDNRB (1.00) EDNRBEDNRA
SCHEMBL7202225 0.80 EDNRB (1.00) EDNRBEDNRA
SCHEMBL5653605 0.80 EDNRB (0.67) EDNRBEDNRA
SCHEMBL6785123 0.79 EDNRB (0.82) EDNRBEDNRA
SCHEMBL6784408 0.79 EDNRA (0.81) EDNRBEDNRA
SCHEMBL5653603 0.78 EDNRB (0.65) EDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0959072-B1 Sulfonamide derivative and process for preparing the same TANABE SEIYAKU CO (JP) 2002-09-25 EP claimed
EP-0959072-B1 Sulfonamide derivative and process for preparing the same TANABE SEIYAKU CO (JP) 2002-09-25 EP disclosed
EP-0959072-A1 Sulfonamide derivative and process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 1999-11-24 EP disclosed
EP-0743307-A1 Sulfonamide derivative and process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 1996-11-20 EP disclosed