Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.60 |
| ▸ | HTR1B | P28222 | 12/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR1F | P30939 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480774 | 1.00 | HTR1D (0.60) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9527462 | 0.88 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9793622 | 0.88 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9527471 | 0.88 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9793627 | 0.88 | HTR1D (0.56) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3260325 | 0.87 | HTR1D (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3260327 | 0.87 | HTR1D (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9764575 | 0.82 | MAPT (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9764568 | 0.82 | MAPT (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7013891 | 0.82 | HTR1D (0.66) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721453-B1 | PROCESS FOR THE PREPARATION OF N-METHYL-3-(1-METHYL-4-PIPERIDINYL)-14-INDOLE-5-ETHANESULPHONAMIDE | GLAXO GROUP LTD (GB) | 2002-11-20 | — | — | EP | disclosed |
| US-5786473-A | Process for the preparation of n-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulphonamide | GLAXO GROUP LIMITED (GB) | 1998-07-28 | — | — | US | disclosed |
| US-5659040-A | Process for the preparation of N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulphonamide | GLAXO GROUP LIMITED (GB) | 1997-08-19 | — | — | US | disclosed |
| EP-0721453-A1 | PROCESS FOR THE PREPARATION OF N-METHYL-3-(1-METHYL-4-PIPERIDINYL)-14-INDOLE-5-ETHANESULPHONAMIDE | GLAXO GROUP LIMITED (GB) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009166-A1 | PROCESS FOR THE PREPARATION OF N-METHYL-3-(1-METHYL-4-PIPERIDINYL)-14-INDOLE-5-ETHANESULPHONAMIDE | GLAXO GROUP LIMITED (GB) | 1995-04-06 | — | — | WO | disclosed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |