Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | BLM | P54132 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482826 | 0.80 | TOP1 (0.35) | — | |
| SCHEMBL7480517 | 0.79 | PARP1 (0.50) | HSD17B10ALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL7482186 | 0.74 | KDM4E (0.36) | HSD17B10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7480329 | 0.73 | HRH2 (0.46) | TDP1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7480746 | 0.72 | PARP1 (0.36) | HSD17B10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7485924 | 0.68 | PARP1 (0.39) | TDP1HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL15730718 | 0.67 | POLQ (0.33) | — | |
| SCHEMBL28322329 | 0.67 | HCAR2 (0.38) | TDP1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL10191701 | 0.66 | IGF1R (0.47) | TDP1HSD17B10ALDH1A1BLMRECQL | |
| SCHEMBL2614373 | 0.64 | IGF1R (0.39) | TDP1HSD17B10ALDH1A1BLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |