Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2222074 | 0.76 | KDM4E (0.48) | MAPK1KDM4EMAOANPSR1ATM | |
| Iodide SCHEMBL2220742 | 0.76 | KDM4E (0.48) | MAPK1KDM4EMAOANPSR1ATM | |
| SCHEMBL13737543 | 0.76 | MEN1 (0.67) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL29543474 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL11875421 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL29437946 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL29067593 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL4368339 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL28694051 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA | |
| SCHEMBL49870 | 0.76 | MEN1 (0.61) | KMT2AMEN1MAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1038873-B1 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | SERVIER LAB (FR) | 2002-05-02 | — | — | EP | disclosed |
| EP-1038873-B1 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | SERVIER LAB (FR) | 2002-05-02 | — | — | EP | disclosed |
| US-6153640-A | FOR TREATING DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, IMPULSIVE DISORDERS, DRUG ABUSE OR ANXIETY | ADIR ET COMPAGNIE (FR) | 2000-11-28 | — | — | US | disclosed |
| US-6153640-A | FOR TREATING DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, IMPULSIVE DISORDERS, DRUG ABUSE OR ANXIETY | ADIR ET COMPAGNIE (FR) | 2000-11-28 | — | — | US | disclosed |
| EP-1038873-A3 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-10-04 | — | — | EP | disclosed |
| EP-1038873-A2 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |
| EP-1038873-A2 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |
| EP-1038873-A2 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |