Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 6/20 | 0.46 |
| ▸ | PARP1 | P09874 | 8/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127145 | 0.87 | PKN1 (0.59) | PKN1PKN2RIPK1PARP1PLA2G2A | |
| SCHEMBL7475827 | 0.86 | PKN1 (0.57) | PKN1PKN2RIPK1KDM4ECRBN | |
| SCHEMBL7966462 | 0.85 | PKN1 (0.56) | PKN1PKN2RIPK1KDM4ECRBN | |
| SCHEMBL8952887 | 0.84 | KDM4E (0.62) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL1170810 | 0.83 | PKN1 (0.77) | PKN1PKN2RIPK1DHODHPARP1 | |
| SCHEMBL7477535 | 0.82 | PARP1 (0.68) | PKN1PKN2RIPK1KDM4ECRBN | |
| SCHEMBL24512711 | 0.81 | PKN1 (0.61) | PKN1PKN2RIPK1KDM4ECRBN | |
| SCHEMBL2830150 | 0.81 | PKN1 (0.61) | PKN1PKN2RIPK1KDM4ECRBN | |
| SCHEMBL6366339 | 0.81 | PKN1 (0.61) | PKN1PKN2RIPK1KDM4EHPGD | |
| SCHEMBL1202374 | 0.81 | PKN1 (0.61) | PKN1PKN2RIPK1KDM4ECRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |