Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN12 | Q05209 | 1/20 | 0.60 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 8/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.56 |
| ▸ | MMP3 | P08254 | 2/20 | 0.56 |
| ▸ | MMP13 | P45452 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484741 | 1.00 | PTPN12 (0.60) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL6791768 | 1.00 | PTPN12 (0.60) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL6791775 | 1.00 | PTPN12 (0.60) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7486208 | 0.96 | PTPN12 (0.62) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7486213 | 0.96 | PTPN12 (0.62) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7486647 | 0.96 | PTPN12 (0.62) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7489851 | 0.91 | PTPN12 (0.61) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7484742 | 0.91 | PTPN12 (0.61) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7489859 | 0.91 | PTPN12 (0.61) | PTPN12PTPN22AKR1B1PTPN1MMP3 | |
| SCHEMBL7484734 | 0.91 | PTPN12 (0.61) | PTPN12PTPN22AKR1B1PTPN1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192143-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | claimed |
| WO-2000076987-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | claimed |
| EP-1192143-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076987-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |