SCHEMBL7485192

SCHEMBL7485192

CN(c1nc(-c2ccccc2)c(-c2ccccc2)o1)C1CCc2c(OCC(=O)O)cccc21

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 12/20 0.48
FABP4 P15090 1/20 0.41
PTGDR Q13258 6/20 0.41
PPARD Q03181 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NR4A2 P43354 2/20 0.39
ACHE P22303 1/20 0.39
PTGDR2 Q9Y5Y4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7494420 0.91 PTGIR (0.45) PTGIRKDM4EMEN1ALDH1A1CYP1A2
SCHEMBL7496987 0.88 NR4A2 (0.49) PTGIRFABP4PTGDRPPARDKDM4E
SCHEMBL7499163 0.84 PTGIR (0.49) PTGIRPTGDR
SCHEMBL7495137 0.82 PTGIR (0.46) PTGIRFABP4PTGDRPPARDKDM4E
SCHEMBL7497865 0.82 PTGIR (0.46) PTGIRFABP4PTGDRPPARDKDM4E
SCHEMBL7489527 0.82 PTGIR (0.51) PTGIRPPARDNR4A2
SCHEMBL7498928 0.82 PTGIR (0.45) PTGIRFABP4PPARDKDM4ECYP3A4
SCHEMBL5212415 0.81 PTGIR (0.46) PTGIRPTGDRACHEPTGDR2
SCHEMBL8589864 0.81 PTGIR (0.45) PTGIRPPARDKDM4ECYP3A4HPGD
SCHEMBL7488291 0.81 PTGIR (0.46) PTGIRFABP4PTGDRPPARDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842161-B1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO (JP) 2002-09-18 EP disclosed
EP-1213285-A2 4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed
US-6300344-B1 FOR THERAPEUTIC AND/OR PROPHYLACTIC TREATMENT OF ARTERIAL OBSTRUCTION, CEREBROVASCULAR DISEASE, HEPATIC CIRRHOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASE, RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-09 US disclosed
US-5972965-A USEFUL FOR INHIBITION OF PLATELET AGGREGATION, VASODILATION, ANTIHYPERTENSIVE ACTIVITY AND PROSTAGLANDIN AGONIST FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0842161-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-20 EP disclosed
WO-1997003973-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-06 WO disclosed