Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485382 | 0.95 | P2RY2 (0.51) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7488312 | 0.92 | P2RY2 (0.48) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7489002 | 0.91 | P2RY2 (0.50) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7491112 | 0.90 | P2RY2 (0.49) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7489024 | 0.85 | P2RY2 (0.50) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7486203 | 0.83 | P2RY2 (0.50) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7492393 | 0.82 | P2RY2 (0.41) | P2RY2ALDH1A1TDP1 | |
| SCHEMBL7487085 | 0.82 | P2RY2 (0.49) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7490967 | 0.82 | P2RY2 (0.50) | P2RY2GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7503322 | 0.81 | P2RY2 (0.43) | P2RY2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | claimed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | claimed |
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |