Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | GFER | P55789 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30170649 | 0.84 | KMT2A (0.50) | MEN1KMT2AGFERHTR2CKDM4E | |
| SCHEMBL2210096 | 0.82 | MEN1 (1.00) | MEN1KMT2AGFERHPGDMAPT | |
| SCHEMBL27829670 | 0.81 | KMT2A (0.72) | MEN1KMT2AGFERHPGDMAPT | |
| SCHEMBL12786172 | 0.79 | KMT2A (0.70) | MEN1KMT2AGFERHPGDMAPT | |
| SCHEMBL31678612 | 0.79 | KDM4E (0.52) | MEN1KMT2AHPGDHTR2CMAPT | |
| SCHEMBL1396118 | 0.79 | KMT2A (0.70) | MEN1KMT2AGFERHPGDTSHR | |
| SCHEMBL1102295 | 0.79 | MEN1 (0.55) | MEN1KMT2AGFERHPGDTSHR | |
| SCHEMBL3669381 | 0.79 | MEN1 (0.55) | MEN1KMT2AGFERHPGDTSHR | |
| SCHEMBL21221773 | 0.79 | KMT2A (0.71) | MEN1KMT2AMAPTHSD17B10PKM | |
| SCHEMBL1091847 | 0.77 | KMT2A (0.54) | MEN1KMT2AGFERHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346622-B1 | ENANTIOMORPHS AND ISOMERS | ABBOTT LABORATORIES | 2002-02-12 | — | — | US | disclosed |
| EP-1025100-B1 | 3-SUBSTITUTED TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVES, METHOD FOR PRODUCING THE SAME, AND THEIR USE | BASF AG (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-1140099-A1 | UTILISATION OF 2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND 3-SUBSTITUTED TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVES FOR THE PROPHYLAXIS AND THERAPY OF CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | disclosed |
| EP-1034170-A1 | 2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND THEIR USE AS SEROTONIN ANTAGONISTS (5-HT1A, 5-HT1B AND 5-HT1D) | BASF AKTIENGESELLSCHAFT (DE) | 2000-09-13 | — | — | EP | disclosed |
| WO-2000041697-A1 | UTILISATION OF 2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND 3-SUBSTITUTED TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVES FOR THE PROPHYLAXIS AND THERAPY OF CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |
| WO-1999020616-A1 | 2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND THEIR USE AS SEROTONIN ANTAGONISTS (5-HT1A, 5-HT1B AND 5-HT1D) | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-29 | — | — | WO | disclosed |