Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | CA12 | O43570 | 3/20 | 0.66 |
| ▸ | CA1 | P00915 | 3/20 | 0.66 |
| ▸ | CA2 | P00918 | 3/20 | 0.66 |
| ▸ | CA3 | P07451 | 3/20 | 0.66 |
| ▸ | CA4 | P22748 | 3/20 | 0.66 |
| ▸ | CA6 | P23280 | 3/20 | 0.66 |
| ▸ | CA5A | P35218 | 3/20 | 0.66 |
| ▸ | CA7 | P43166 | 3/20 | 0.66 |
| ▸ | CA9 | Q16790 | 3/20 | 0.66 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.66 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487480 | 1.00 | KDM4E (0.66) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL17365409 | 0.86 | KDM4E (0.55) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL30744068 | 0.86 | KDM4E (0.55) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL28483328 | 0.86 | KDM4E (0.55) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL14898184 | 0.83 | KDM4E (0.66) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL16153884 | 0.81 | NPSR1 (0.51) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| Caffeic Acid SCHEMBL8028609 | 0.81 | KDM4E (0.86) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL11586243 | 0.80 | MAPT (0.77) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| SCHEMBL30383805 | 0.80 | MAPT (0.77) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 | |
| Caffeic Acid SCHEMBL7064846 | 0.80 | KDM4E (1.00) | KDM4EAKR1B1HSD17B10NFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6306870-B1 | PHOSPHODIESTERASE ENZYME INHIBITORS, CARDIOVASCULAR DISORDERS AND SEXUAL DISORDERS | ICOS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0912567-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043287-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |
| EP-0028063-B1 | PHENOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-06-13 | — | — | EP | disclosed |
| EP-0028063-A1 | Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1981-05-06 | — | — | EP | disclosed |