Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 16/20 | 0.71 |
| ▸ | KDR | P35968 | 12/20 | 0.71 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487980 | 1.00 | PDGFRA (0.71) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7479901 | 0.90 | PDGFRA (0.71) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7479897 | 0.90 | PDGFRA (0.71) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7485409 | 0.86 | PDGFRA (0.73) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7485401 | 0.86 | PDGFRA (0.73) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7488625 | 0.86 | KDR (0.71) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7488626 | 0.86 | KDR (0.71) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7479716 | 0.83 | PDGFRA (0.79) | PDGFRAKDRKITAXLFGFR2 | |
| SCHEMBL7485134 | 0.83 | PDGFRA (1.00) | PDGFRAKDRKIT | |
| SCHEMBL5825864 | 0.78 | PDGFRA (0.80) | PDGFRAKDRKITAXLFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |