Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10925309 | 0.99 | TOP2A (0.49) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL11127481 | 0.93 | TOP2A (0.44) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL7495129 | 0.89 | TOP2A (0.50) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL10925471 | 0.88 | TOP2A (0.39) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL11748467 | 0.86 | TOP2A (0.57) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL8486664 | 0.86 | TOP2A (0.48) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL8488003 | 0.86 | TOP2A (0.46) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL10812083 | 0.85 | TOP2A (0.47) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL10477218 | 0.85 | TOP2A (0.58) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL7494000 | 0.85 | TOP2A (0.68) | TOP2ATOP2BPOLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | claimed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | claimed |
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | disclosed |
| EP-0812192-A4 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0812192-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026723-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1996-09-06 | — | — | WO | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |