Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488129 | 1.00 | CA12 (0.44) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL7487397 | 0.88 | CA12 (0.43) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL7487390 | 0.88 | CA12 (0.43) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL6796859 | 0.82 | CYP19A1 (0.47) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL6796866 | 0.82 | CYP19A1 (0.47) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL7362392 | 0.82 | MAPT (0.48) | TLR4TLR2NPC1HPGDHTT | |
| SCHEMBL7493488 | 0.82 | MAPT (0.48) | TLR4TLR2NPC1HPGDHTT | |
| SCHEMBL6801720 | 0.81 | NPC1 (0.50) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL6801723 | 0.81 | NPC1 (0.50) | CA12CA1CA2CA9TLR4 | |
| SCHEMBL6796987 | 0.80 | NPC1 (0.55) | CA12CA1CA2CA9TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |