SCHEMBL7488187

SCHEMBL7488187

CCOc1ccc(-c2nc(-c3cc(C=O)c(OCOC)c(C(=O)OC)c3)cs2)cc1OCC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49
PDE4C Q08493 1/20 0.49
PDE4D Q08499 1/20 0.49
KDM4E B2RXH2 5/20 0.40
ALDH1A1 P00352 4/20 0.40
EIF4E P06730 4/20 0.39
FPR2 P25090 1/20 0.38
MEN1 O00255 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
S1PR1 P21453 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 2/20 0.36
THRB P10828 1/20 0.36
HSD17B10 Q99714 1/20 0.36
DCK P27707 1/20 0.36
CDC25A P30304 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7488190 0.94 PDE4A (0.48) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL29475569 0.88 PDE4A (0.52) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7492016 0.88 PDE4A (0.52) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7498190 0.86 PDE4A (0.47) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7501601 0.86 PDE4A (0.47) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7501605 0.86 PDE4A (0.47) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7494889 0.85 PDE4A (0.48) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7701947 0.84 PDE4A (0.47) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7491939 0.84 PDE4A (0.45) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL7491927 0.84 PDE4A (0.45) PDE4APDE4BPDE4CPDE4DKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934937-B1 Azole derivatives as superoxide radical inhibitor OTSUKA PHARMA CO LTD (JP) 2002-02-27 EP disclosed
US-RE37556-E1 (ALKOXYPHENYL)THIAZOLE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2002-02-19 US disclosed
EP-1130017-A2 Azole derivatives and their use as superoxide radical inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2001-09-05 EP disclosed
US-6080764-A PROTECTING VARIOUS TISSUE CELLS FROM DISTURBANCES ASSOCIATED WITH ISCHEMIA AND BLOOD REPERFUSION IN HEART, BRAIN, KIDNEY, LUNG AND DIGESTIVE TRACT BY INHIBITING SUPEROXIDE-RELEASE BY NEUTROPHILIC LEUKOCYTES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2000-06-27 US disclosed
EP-0513387-B1 THIAZOLE DERIVATIVES AS ACTIVE OXYGEN INHIBITORS OTSUKA PHARMA CO LTD (JP) 2000-03-01 EP disclosed
EP-0934937-A1 Azole derivatives as superoxide radical inhibitor OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1999-08-11 EP disclosed
US-5677319-A THIAZOLE DERIVATIVE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-10-14 US disclosed
US-5643932-A PREVENTS CELL DAMAGE AFTER ISCHEMIA AND RE-PERFUSION, SUBSTITUTED THIAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0513387-A1 ACTIVE OXYGEN INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1992-11-19 EP disclosed