Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 10/20 | 0.76 |
| ▸ | JAK1 | P23458 | 10/20 | 0.76 |
| ▸ | TYK2 | P29597 | 5/20 | 0.76 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.71 |
| ▸ | STK3 | Q13188 | 3/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.71 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.71 |
| ▸ | MARK3 | P27448 | 2/20 | 0.71 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.71 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.71 |
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | LCK | P06239 | 2/20 | 0.71 |
| ▸ | FYN | P06241 | 2/20 | 0.71 |
| ▸ | RET | P07949 | 2/20 | 0.71 |
| ▸ | DMPK | Q09013 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683647 | 0.94 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL2320931 | 0.94 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL7495463 | 0.92 | JAK3 (0.73) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL7494296 | 0.91 | JAK3 (0.75) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL7495497 | 0.90 | JAK3 (0.89) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL28413805 | 0.88 | JAK3 (0.89) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL24327026 | 0.86 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL17279276 | 0.86 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL22511887 | 0.86 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL13956994 | 0.86 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235830-A2 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001042246-A2 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-06-14 | — | — | WO | disclosed |