Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 14/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487336 | 0.90 | MAPT (0.60) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7478654 | 0.86 | BLM (0.61) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7481487 | 0.82 | BLM (0.59) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7482056 | 0.81 | BLM (0.58) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7476849 | 0.80 | BLM (0.52) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7475135 | 0.79 | BLM (0.62) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7477767 | 0.78 | TP53 (0.52) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7426821 | 0.77 | BLM (0.53) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7487945 | 0.77 | BLM (0.61) | BLMMAPTNPC1RAB9ATP53 | |
| SCHEMBL7473728 | 0.77 | MAPT (0.57) | BLMMAPTNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |