Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372928 | 1.00 | TOP2A (0.54) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL6750941 | 0.87 | TOP2A (0.47) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL11747964 | 0.86 | TOP2A (0.58) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL11747960 | 0.86 | TOP2A (0.56) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL11748467 | 0.86 | TOP2A (0.57) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL29358201 | 0.83 | TOP2A (0.55) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL11750031 | 0.79 | TOP2A (0.54) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL10477218 | 0.77 | TOP2A (0.58) | TOP2ATOP2BRAD52POLBNPC1 | |
| SCHEMBL11745243 | 0.74 | TOP2A (0.37) | TOP2ATOP2BKMT2ACRHR1LMNA | |
| SCHEMBL10477217 | 0.73 | TOP2A (0.49) | TOP2ATOP2BRAD52POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-4026899-A | PARASITICIDES | PARKE, DAVIS & COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-3963740-A | PARASITICIDE | PARKE, DAVIS & COMPANY (US) | 1976-06-15 | — | — | US | disclosed |