Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MGAT2 | Q10469 | 3/20 | 0.49 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.46 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490795 | 1.00 | MEN1 (0.56) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7488835 | 0.94 | MGAT2 (0.55) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7497322 | 0.94 | MGAT2 (0.55) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7493708 | 0.91 | BRD4 (0.55) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7493713 | 0.91 | BRD4 (0.55) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7497551 | 0.91 | BRD4 (0.52) | MEN1KMT2APOLBMAPTBRD4 | |
| SCHEMBL7485899 | 0.90 | BRD4 (0.53) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7497525 | 0.90 | BRD4 (0.51) | MEN1KMT2APOLBMAPTBRD4 | |
| SCHEMBL7485892 | 0.90 | BRD4 (0.53) | MEN1KMT2APOLBMAPTGAA | |
| SCHEMBL7495325 | 0.90 | BRD4 (0.51) | MEN1KMT2APOLBMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224169-A2 | PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027080-A2 | 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS KINASE AND CYCLIN/CDK COMPLEX INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |