Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 20/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 20/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 17/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 17/20 | 1.00 |
| ▸ | PDE5A | O76074 | 13/20 | 1.00 |
| ▸ | PDE1A | P54750 | 13/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 13/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 13/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491542 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7497395 | 0.92 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7495374 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6625947 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7491123 | 0.85 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7499989 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7499992 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7496020 | 0.84 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8342507 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL13350333 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | claimed |
| US-5852190-A | Diazepinoindoles as phosphodiesterase IV inhibitors | INSTITUT DE RECHERCHE JOUVEINAL SA (FR) | 1998-12-22 | — | — | US | claimed |
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |