Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 11/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.57 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5376663 | 0.81 | NTRK1 (0.43) | NTRK1KDRPDPK1HDAC3HDAC4 | |
| SCHEMBL5369945 | 0.80 | NTRK1 (0.43) | NTRK1PDPK1TLK2PAK4MAPT | |
| SCHEMBL5364426 | 0.80 | RET (0.67) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL5360816 | 0.79 | PDGFRB (0.62) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL5357876 | 0.78 | HDAC3 (0.69) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL30997330 | 0.78 | NTRK1 (1.00) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL29264970 | 0.78 | NTRK1 (1.00) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL29264965 | 0.78 | NTRK1 (1.00) | NTRK1RETKDRPDPK1PDGFRB | |
| SCHEMBL5367043 | 0.78 | NTRK1 (0.66) | NTRK1PDPK1TLK2JAK3 | |
| SCHEMBL5364424 | 0.77 | KDR (0.72) | NTRK1RETKDRPDPK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |