Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | MGAT2 | Q10469 | 4/20 | 0.43 |
| ▸ | MGAT1 | P26572 | 2/20 | 0.43 |
| ▸ | MGAT3 | Q09327 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494033 | 1.00 | BRD4 (0.45) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491753 | 0.92 | MGAT2 (0.43) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491747 | 0.92 | MGAT2 (0.43) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491538 | 0.92 | BRD4 (0.45) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491536 | 0.92 | BRD4 (0.45) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7496646 | 0.90 | BRD4 (0.40) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7496119 | 0.89 | BRD4 (0.43) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7496112 | 0.89 | BRD4 (0.43) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491238 | 0.88 | BRD4 (0.46) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7491234 | 0.88 | BRD4 (0.46) | BRD4MGAT2MGAT1MGAT3BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224169-A2 | PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027080-A2 | 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS KINASE AND CYCLIN/CDK COMPLEX INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |