Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 6/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.44 |
| ▸ | EED | O75530 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | HLA-A | P04439 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504280 | 0.95 | KCNH2 (0.52) | KCNH2TACR2SSTR5MC4R | |
| SCHEMBL7497058 | 0.94 | KCNH2 (0.50) | KCNH2TACR2SSTR5EEDTP53 | |
| SCHEMBL7494668 | 0.93 | KCNH2 (0.49) | KCNH2TACR2SSTR5EEDTP53 | |
| SCHEMBL7494148 | 0.92 | KCNH2 (0.47) | KCNH2TACR2SSTR5OPRM1OPRD1 | |
| SCHEMBL7495286 | 0.92 | KCNH2 (0.51) | KCNH2TACR2SSTR5EEDTP53 | |
| SCHEMBL7499921 | 0.92 | KCNH2 (0.62) | KCNH2IRAK4TACR2SSTR5EED | |
| SCHEMBL7496225 | 0.92 | TACR2 (0.52) | KCNH2TACR2 | |
| SCHEMBL7501800 | 0.92 | KCNH2 (0.49) | KCNH2IRAK4TACR2SSTR5EED | |
| SCHEMBL7496466 | 0.91 | KCNH2 (0.49) | KCNH2TACR2SSTR5EEDTP53 | |
| SCHEMBL7491258 | 0.91 | KCNH2 (0.48) | KCNH2TACR2SSTR5EEDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |