Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.72 |
| ▸ | ABL1 | P00519 | 8/20 | 0.72 |
| ▸ | ABL2 | P42684 | 5/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | PRKCA | P17252 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.50 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27627681 | 0.85 | EGFR (0.91) | EGFRABL1ABL2PRKCA | |
| SCHEMBL29795688 | 0.85 | EGFR (0.91) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2463632 | 0.84 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL29406611 | 0.84 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL7495632 | 0.84 | EGFR (0.72) | EGFRABL1ABL2SRCPRKCA | |
| SCHEMBL7498843 | 0.83 | EGFR (0.71) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL2464688 | 0.79 | EGFR (1.00) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL7491933 | 0.79 | EGFR (0.72) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL1096684 | 0.78 | EGFR (0.57) | EGFRABL1ABL2SRCPRKCA | |
| SCHEMBL4769590 | 0.77 | TTBK1 (0.60) | EGFRABL1ABL2SRCTTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | claimed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | claimed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | claimed |
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |