Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 5/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494816 | 0.89 | GRIA1 (0.38) | MAPK14MAPK11MAPK13MAPK12CSNK1D | |
| SCHEMBL7501614 | 0.88 | GRIA1 (0.39) | MAPK14MAPK11MAPK13MAPK12CSNK1D | |
| SCHEMBL7494995 | 0.87 | CSNK1D (0.39) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL7496132 | 0.87 | GRIA1 (0.38) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL7496496 | 0.84 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL7488387 | 0.84 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| Hydrochloric Acid SCHEMBL7495189 | 0.83 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL24553785 | 0.80 | CSNK1E (0.44) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL29682898 | 0.80 | CSNK1E (0.44) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL7494623 | 0.79 | MAPK14 (0.43) | MAPK14MAPK11MAPK13MAPK12ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686156-B1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-07-17 | — | — | EP | disclosed |
| EP-0686156-A1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019350-A1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |