SCHEMBL7495586

SCHEMBL7495586

CCCCOc1ccc(C(=NOC)C(C)=NOCc2ccccc2C(=NOC)C(=O)NC)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.43
PLK1 P53350 2/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
MMP1 P03956 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
FAAH O00519 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
PPARD Q03181 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7505105 0.96 HIF1A (0.43) HIF1APLK1ALDH1A1LMNAGAA
SCHEMBL7503272 0.88 HIF1A (0.43) HIF1AALDH1A1LMNAGAAMAPT
SCHEMBL17937974 0.87 HIF1A (0.47) HIF1AALDH1A1LMNANPC1RAB9A
SCHEMBL828434 0.87 HIF1A (0.47) HIF1AALDH1A1LMNANPC1RAB9A
SCHEMBL828435 0.87 HIF1A (0.47) HIF1AALDH1A1LMNANPC1RAB9A
SCHEMBL13148668 0.87 HIF1A (0.47) HIF1AALDH1A1LMNANPC1RAB9A
SCHEMBL7500390 0.87 HIF1A (0.54) HIF1APLK1MAPTMEN1NPC1
SCHEMBL7171770 0.86 HIF1A (0.43) HIF1AALDH1A1LMNAMAPTMEN1
SCHEMBL7171768 0.86 HIF1A (0.43) HIF1AALDH1A1LMNAMAPTMEN1
SCHEMBL7493427 0.85 HIF1A (0.43) HIF1APLK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420423-B1 PESTICIDE FOR USE ON CEREALS, BEETS, FRUITS, BERRIES, AND BEANS; KILLS MITES, INSECTS, TERMITES, LICE, FLEAS, AND FUNGUS; TOLERATED WELL BE ANIMALS, PLANTS, AND FISH BAYER AKTIENGESELLSCHAFT (DE) 2002-07-16 US disclosed
EP-1207152-A2 Pesticides Bayer Aktiengesellschaft (DE) 2002-05-22 EP disclosed
US-5985921-A OXIDATION AND HYDROGENATION OF COMPOUNDS TO FORM INSECTICIDES AS AGROCHEMICALS NOVARTIS CORPORATION (US) 1999-11-16 US disclosed
EP-0865424-A1 PESTICIDES Novartis AG (CH) 1998-09-23 EP disclosed
WO-1997020809-A1 PESTICIDES NOVARTIS AG (CH) 1997-06-12 WO disclosed