Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.65 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.65 |
| ▸ | ITGAL | P20701 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31050989 | 1.00 | ITGB2 (0.65) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL11701763 | 1.00 | ITGB2 (0.65) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL11396694 | 0.91 | SMN1; SMN2 (0.74) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL21907958 | 0.91 | SMN1; SMN2 (0.67) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| Piperazine SCHEMBL3566816 | 0.90 | ITGB2 (0.74) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL31123014 | 0.86 | SMN1; SMN2 (0.74) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL15485033 | 0.83 | ITGB2 (0.64) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| Piperidine SCHEMBL15864138 | 0.83 | ITGB2 (0.64) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL27348685 | 0.81 | SMN1; SMN2 (0.48) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL27504816 | 0.80 | ITGB2 (0.67) | ITGB2ICAM1ITGALSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3112971-A | — | — | None | — | — | JP | disclosed |
| EP-0417671-A3 | 3,4,5,6-TETRAHYDRO-2H-1,7,4-BENZODIOXAZONINES AS CARDIOVASCULAR AGENTS | — | 1991-08-14 | — | — | EP | disclosed |
| JP-H03112971-A | 3,4,5,6-TETRAHYDRO-2H-1,7,4-BENZODIOXAZONINE AS DRUG ACTING ON CARDIAC BLOOD VESSEL | BERLEX LAB INC | 1991-05-14 | — | — | JP | disclosed |
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | disclosed |