Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 20/20 | 0.45 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | TACR3 | P29371 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503211 | 0.94 | TACR2 (0.42) | TACR2TACR1TACR3 | |
| SCHEMBL7494958 | 0.94 | TACR2 (0.44) | TACR2TACR1TACR3 | |
| SCHEMBL7499569 | 0.93 | TACR2 (0.43) | TACR2TACR1TACR3 | |
| SCHEMBL7494607 | 0.92 | KCNH2 (0.40) | TACR2TACR1 | |
| SCHEMBL7491872 | 0.91 | TACR2 (0.44) | TACR2TACR1TACR3 | |
| SCHEMBL7500764 | 0.91 | TACR2 (0.44) | TACR2TACR1TACR3 | |
| SCHEMBL7496633 | 0.91 | TACR2 (0.43) | TACR2TACR1TACR3 | |
| SCHEMBL7497198 | 0.90 | TACR2 (0.47) | TACR2TACR1TACR3 | |
| SCHEMBL8520359 | 0.90 | TACR2 (0.46) | TACR2TACR1TACR3 | |
| SCHEMBL7472253 | 0.90 | HRH1 (0.50) | TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0888336-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030989-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |