Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.60 |
| ▸ | PRKCA | P17252 | 6/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500405 | 0.86 | CCNE2 (0.50) | GSK3BPRKCA | |
| SCHEMBL668748 | 0.85 | CCNE2 (0.57) | — | |
| SCHEMBL7502427 | 0.85 | GSK3B (0.75) | GSK3BPRKCAKDR | |
| Enmd-981693 SCHEMBL608128 | 0.84 | CCNE2 (0.69) | GSK3B | |
| Enmd-981693 SCHEMBL29350364 | 0.84 | CCNE2 (0.69) | GSK3B | |
| SCHEMBL7059442 | 0.83 | GSK3B (0.57) | GSK3BPRKCA | |
| SCHEMBL8161298 | 0.83 | CCNE2 (0.71) | GSK3BPRKCAKDR | |
| SCHEMBL7502568 | 0.81 | GSK3B (0.58) | GSK3BPRKCA | |
| SCHEMBL7508119 | 0.81 | CCNE2 (0.56) | — | |
| SCHEMBL6948330 | 0.80 | CCNE2 (0.54) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |