Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.62 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497083 | 0.83 | LCK (0.63) | LCKMAP3K14ROCK1MKNK1MKNK2 | |
| SCHEMBL7021615 | 0.77 | LCK (1.00) | LCKMKNK1MKNK2 | |
| SCHEMBL7022991 | 0.76 | LCK (0.52) | LCKMAP3K14ROCK1MKNK2 | |
| SCHEMBL7497256 | 0.73 | LCK (0.55) | LCKMAP3K14ROCK1MKNK1MKNK2 | |
| SCHEMBL7020876 | 0.73 | FGFR1 (0.53) | LCKMKNK1MKNK2 | |
| SCHEMBL7022083 | 0.72 | ROCK1 (0.59) | LCKROCK1MKNK1MKNK2 | |
| SCHEMBL7017856 | 0.70 | MKNK1 (0.50) | LCKROCK1MKNK1MKNK2 | |
| SCHEMBL7105662 | 0.70 | LCK (0.88) | LCKMKNK1MKNK2 | |
| SCHEMBL7017366 | 0.69 | LCK (0.52) | LCKMAP3K14ROCK1 | |
| SCHEMBL7016429 | 0.68 | LCK (0.85) | LCKMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |