Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496713 | 1.00 | HDAC8 (0.42) | HDAC8MAPTNR0B1LMNAMMP1 | |
| SCHEMBL7495854 | 0.96 | HDAC8 (0.44) | HDAC8MAPTNR0B1MMP1MMP3 | |
| SCHEMBL7495862 | 0.96 | HDAC8 (0.44) | HDAC8MAPTNR0B1MMP1MMP3 | |
| SCHEMBL7494331 | 0.88 | MAPT (0.37) | HDAC8MAPTNR0B1TACR1DDB1 | |
| SCHEMBL7494338 | 0.88 | MAPT (0.37) | HDAC8MAPTNR0B1TACR1DDB1 | |
| SCHEMBL7493846 | 0.87 | MEN1 (0.46) | LMNAMMP1MMP3MMP9 | |
| SCHEMBL7493838 | 0.87 | MEN1 (0.46) | LMNAMMP1MMP3MMP9 | |
| SCHEMBL7492804 | 0.87 | CAPN1 (0.40) | MAPTNR0B1 | |
| SCHEMBL7492801 | 0.87 | CAPN1 (0.40) | MAPTNR0B1 | |
| SCHEMBL7491481 | 0.86 | HRH3 (0.44) | MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638075-B1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| WO-1998043649-A2 | AGE PRODUCTION INHIBITORY COMPOSITION COMPRISING A MAILLARD REACTION INHIBITOR AND VITAMIN B¿6? | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-08 | — | — | WO | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |