Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.71 |
| ▸ | KDR | P35968 | 4/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498147 | 1.00 | EGFR (0.71) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7497282 | 0.91 | EGFR (0.82) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7497288 | 0.91 | EGFR (0.82) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7499893 | 0.90 | EGFR (0.83) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7499887 | 0.90 | EGFR (0.83) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7492133 | 0.90 | EGFR (0.70) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL7496939 | 0.90 | EGFR (0.70) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL6807507 | 0.89 | EGFR (0.69) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL6807502 | 0.89 | EGFR (0.69) | EGFRKDRHDAC3HDAC4HDAC1 | |
| SCHEMBL8327218 | 0.87 | EGFR (0.67) | EGFRKDRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1100778-C | Pyrrolopyrimidines and process for their preparation | NOVARTIS CO (CH) | 2003-02-05 | — | — | CN | claimed |
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | claimed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | claimed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | claimed |
| CN-1100778-C | Pyrrolopyrimidines and process for their preparation | NOVARTIS CO (CH) | 2003-02-05 | — | — | CN | disclosed |
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |