Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507056 | 0.92 | MKNK2 (0.63) | MKNK2MKNK1LCKFGFR1 | |
| SCHEMBL7496692 | 0.91 | MKNK1 (0.63) | MKNK2MKNK1LCKFGFR1TP53 | |
| SCHEMBL7505494 | 0.88 | MKNK2 (0.67) | MKNK2MKNK1LCK | |
| SCHEMBL7509083 | 0.87 | MKNK1 (0.67) | MKNK2MKNK1LCK | |
| SCHEMBL7509550 | 0.86 | MKNK2 (0.55) | MKNK2MKNK1LCKTP53 | |
| SCHEMBL7506819 | 0.86 | MKNK1 (0.66) | MKNK2MKNK1LCK | |
| SCHEMBL7497560 | 0.85 | MKNK1 (0.64) | MKNK2MKNK1LCK | |
| SCHEMBL7507697 | 0.85 | MKNK1 (0.70) | MKNK2MKNK1LCK | |
| SCHEMBL7499363 | 0.85 | MKNK1 (0.67) | MKNK2MKNK1LCK | |
| SCHEMBL7501973 | 0.85 | MKNK2 (0.67) | MKNK2MKNK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |