Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6353312 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL6214346 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL15630775 | 0.84 | MAPK1 (0.50) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL13035222 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL25395151 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL25395899 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL7499292 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL4169299 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL15663898 | 0.76 | MAPK1 (0.51) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 | |
| SCHEMBL15664140 | 0.75 | GUCY1B2 (0.48) | SMN1; SMN2MAPK1MAPTRAB9AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971920-B1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| US-6265415-B1 | ANTIULCER AGENT | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0971920-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | Astra Aktiebolag (SE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998037080-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRA AKTIEBOLAG (SE) | 1998-08-27 | — | — | WO | disclosed |