Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.75 |
| ▸ | PDE5A | O76074 | 6/20 | 0.66 |
| ▸ | PDE1A | P54750 | 6/20 | 0.66 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.66 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.65 |
| ▸ | CCKBR | P32239 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492646 | 0.91 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7497465 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7501830 | 0.88 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7495324 | 0.86 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7491635 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7491632 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9120517 | 0.85 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7494421 | 0.85 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7490769 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7490773 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |