SCHEMBL7499185

SCHEMBL7499185

O=C(O)COc1cccc(CC2CCCCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 13/20 0.81
PTGER4 P35408 6/20 0.81
PTGER3 P43115 2/20 0.81
PTGER1 P34995 1/20 0.69
FABP4 P15090 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MEN1 O00255 1/20 0.55
ALDH1A1 P00352 1/20 0.55
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
HPGD P15428 1/20 0.55
KMT2A Q03164 1/20 0.55
HSD17B10 Q99714 1/20 0.55
TBXA2R P21731 1/20 0.48
PTGER2 P43116 1/20 0.48
PTGDR Q13258 1/20 0.48
CPT2 P23786 1/20 0.40
CPT1A P50416 1/20 0.40
CPT1B Q92523 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7499177 1.00 PTGIR (0.81) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL7489580 0.99 PTGIR (0.82) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL7960020 0.97 PTGIR (0.86) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL6616915 0.97 PTGIR (0.86) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL8066001 0.97 PTGIR (0.86) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL8055217 0.93 PTGIR (0.85) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL8073723 0.93 PTGIR (0.85) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL6613103 0.93 PTGIR (0.85) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL7487196 0.91 PTGIR (0.74) PTGIRPTGER4PTGER3PTGER1FABP4
SCHEMBL7487189 0.91 PTGIR (0.74) PTGIRPTGER4PTGER3PTGER1FABP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1213285-A2 4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed
US-6300344-B1 FOR THERAPEUTIC AND/OR PROPHYLACTIC TREATMENT OF ARTERIAL OBSTRUCTION, CEREBROVASCULAR DISEASE, HEPATIC CIRRHOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASE, RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-09 US disclosed
EP-0842161-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-20 EP disclosed
WO-1997003973-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-06 WO disclosed