Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384570 | 0.94 | NPC1 (0.57) | NPC1KMT2AMEN1DNM1 | |
| SCHEMBL1384566 | 0.94 | NPC1 (0.57) | NPC1KMT2AMEN1DNM1 | |
| SCHEMBL7493743 | 0.91 | NPC1 (0.48) | NPC1KMT2AMEN1KCNH2 | |
| SCHEMBL7487764 | 0.91 | MEN1 (0.51) | NPC1KMT2AMEN1 | |
| SCHEMBL1385112 | 0.90 | NPC1 (0.44) | NPC1KMT2AMEN1PIK3CGMAPT | |
| SCHEMBL1385116 | 0.90 | NPC1 (0.44) | NPC1KMT2AMEN1PIK3CGMAPT | |
| SCHEMBL7488509 | 0.86 | NPC1 (0.45) | NPC1KMT2AMEN1 | |
| SCHEMBL1384202 | 0.86 | NPC1 (0.45) | NPC1KMT2AMEN1 | |
| SCHEMBL7496514 | 0.86 | NPC1 (0.40) | NPC1KMT2AMEN1ALOX5ALOX5AP | |
| SCHEMBL1384208 | 0.86 | NPC1 (0.45) | NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | disclosed |