Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 18/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25970734 | 0.88 | POLR1A (0.77) | POLR1ATSHRKCNH2NPSR1HSD17B10 | |
| SCHEMBL7506933 | 0.86 | POLR1A (0.76) | POLR1ATSHRALDH1A1KCNH2NPSR1 | |
| SCHEMBL7496170 | 0.85 | POLR1A (0.71) | POLR1AALDH1A1KCNH2NPSR1 | |
| SCHEMBL17099668 | 0.84 | POLR1A (1.00) | POLR1AKCNH2 | |
| SCHEMBL25970713 | 0.83 | POLR1A (1.00) | POLR1AKCNH2 | |
| SCHEMBL17099655 | 0.83 | POLR1A (1.00) | POLR1AKCNH2 | |
| SCHEMBL25970717 | 0.83 | POLR1A (1.00) | POLR1AKCNH2 | |
| SCHEMBL21836087 | 0.83 | POLR1A (0.58) | POLR1ATSHRALDH1A1KCNH2HSD17B10 | |
| SCHEMBL21836056 | 0.82 | POLR1A (0.57) | POLR1ATSHRALDH1A1KCNH2HSD17B10 | |
| SCHEMBL25345565 | 0.81 | POLR1A (1.00) | POLR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944628-B1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID CO (US) | 2002-06-05 | — | — | EP | claimed |
| US-5908840-A | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents | AMERICAN CYANAMID COMPANY (US) | 1999-06-01 | — | — | US | claimed |
| EP-0944628-B1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID CO (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5908840-A | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents | AMERICAN CYANAMID COMPANY (US) | 1999-06-01 | — | — | US | disclosed |