Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 17/20 | 0.71 |
| ▸ | ECE1 | P42892 | 1/20 | 0.70 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496170 | 0.93 | POLR1A (0.71) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL7504818 | 0.90 | POLR1A (0.68) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL7505939 | 0.85 | POLR1A (0.76) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL7504121 | 0.83 | POLR1A (0.68) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL13248367 | 0.83 | POLR1A (1.00) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL25970712 | 0.83 | POLR1A (0.81) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL25970715 | 0.80 | POLR1A (0.76) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL7503807 | 0.79 | POLR1A (0.76) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL25970726 | 0.79 | POLR1A (0.75) | POLR1AECE1MUS81KCNH2CYP1A2 | |
| SCHEMBL7499404 | 0.78 | POLR1A (0.71) | POLR1AECE1MUS81KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944628-B1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID CO (US) | 2002-06-05 | — | — | EP | claimed |
| EP-0944628-B1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID CO (US) | 2002-06-05 | — | — | EP | disclosed |